I don't even care if this is real or not, but it sure looks real. The lighting looks like they're outdoors; it doesn't look like a cheap green screen effect, and the car drives over the same lamp shadow that Kobe is standing on.
Also since Ronny is in the bit with him it makes it "feel" more real. But it's actually part of a Nike ad, so.... it's probably not. But who cares! Awesome vid anyhow.
Judge for yourself.
Ran across this parody video on CollegeHumor.com.
For more about Kobe, check out his official website, home of the Mamba